SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans
نویسندگان
چکیده
منابع مشابه
Endothelial Vasodilator Angiotensin Receptors are Changing in Mice with Ageing
Background: The vascular function of Angiotensin II-type-2 receptors in adults is controversial. We sought their location and function in mouse aortic rings at young and old mice. Materials and Methods: Male C57Bl mice (aged 4 and 14 months) were killed by CO2. The descending thoracic aorta was cleaned and dissected into rings. Aortic rings were mounted in Krebs’ solution at 37 °C an...
متن کاملendothelial vasodilator angiotensin receptors are changing in mice with ageing
background: the vascular function of angiotensin ii-type-2 receptors in adults is controversial. we sought their location and function in mouse aortic rings at young and old mice. materials and methods: male c57bl mice (aged 4 and 14 months) were killed by co2. the descending thoracic aorta was cleaned and dissected into rings. aortic rings were mounted in krebs’ solution at 37 °c and then setu...
متن کاملDeficiency in Melanocortin 1 Receptor Signaling Predisposes to Vascular Endothelial Dysfunction and Increased Arterial Stiffness in Mice and Humans.
OBJECTIVE The melanocortin 1 receptor (MC1-R) is expressed by vascular endothelial cells and shown to enhance nitric oxide (NO) availability and vasodilator function on pharmacological stimulation. However, the physiological role of MC1-R in the endothelium and its contribution to vascular homeostasis remain unresolved. We investigated whether a lack of functional MC1-R signaling carries a phen...
متن کاملthe past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
Sildenafil and endothelial dysfunction in humans.
Although it is well established that ischemic preconditioning (IPC) and pharmacological preconditioning (PPC) protect cardiac myocytes against reversible and irreversible injury and the genesis of cardiac arrhythmias1 in all animal species and humans, the effect of IPC and PPC on endothelial dysfunction has been less thoroughly studied. In this regard, the first article to clearly establish tha...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2011
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2011.211219